TP53
tumor protein p53
Click an exon block to inspect its genomic coordinates and length.
CDS UTR / non-coding exon Intron · Proportional genomic coordinates
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
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Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence.
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.
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Negatively regulates cell division by controlling expression of a set of genes required for this process.
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One of the activated genes is an inhibitor of cyclin-dependent kinases.
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Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Hover a bar for its exact value. Linear scale preserves proportional differences. · HPA consensus tissue dataset.
Associated conditions
Associations are reproduced from the named sources and do not independently establish causality. Not for clinical interpretation.
- 2023
- 2010TP53 mutations in human cancers: origins, consequences, and clinical use.
Olivier M, Hollstein M, Hainaut P
Cold Spring Harbor perspectives in biology · PMID 20182602
- 2016TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data.
Bouaoun L, Sonkin D, Ardin M, Hollstein M, Byrnes G, et al.
Human mutation · PMID 27328919
- 2011TP53 mutations in nonsmall cell lung cancer.
Mogi A, Kuwano H
Journal of biomedicine & biotechnology · PMID 21331359
- 2020Li-Fraumeni syndrome heterogeneity.
Gargallo P, Yáñez Y, Segura V, Juan A, Torres B, et al.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · PMID 31691207